Structural reorganization of the third metatarsal bone shaft after autogenous plasty of the tibial portion of the sciatic nerve

Introduction. The effect of sciatic nerve neurectomy on the loss bone density femur and tibia has been proven in experimental biological models, but condition bones distal limb parts after surgeries, aimed at innervation restoring not studied. Purpose to reveal structural changes shaft third metatarsal primary autogenous plasty resection defect tibial portion rats. Materials Methods. Autologous neuroplasty was performed 16 Wistar rats (aged 8-10 months). In 4 6 months surgery, animals were euthanized, control 7 intact appropriate age time euthanasia. ratio fuchsinophilic anilinophilic structures cortical plate determined using method point-count volumemetry images transverse sections shaft, stained according Masson. thickness measured, numerical density, area, diameter osteons Haversian canals determined. Results. After experiment, compared with control, a decrease proportion mineralized by 15% (p=0.0001) revealed, its reduced 12.7% (p=0.0184), signs osteolysis expressed osteon layer, reduced, as well their dimensional characteristics, dilated noted. period months, did have significant differences from norm (p=0.2067), however, progressed 33.6% (p=0.0001). values osteons, area diameters remained. increased over time. Conclusions. developed 2D model for assessing denervation osteopenia is applicable further studies rehabilitation effects that accelerate improve reinnervation.